The ovarian reserve defines female reproductive lifespan, which in humans spans decades. The ovarian reserve consists of oocytes residing in primordial follicles arrested in meiotic prophase I and is maintained independent of DNA replication and cell proliferation, thereby lacking stem cell‐based maintenance. Largely unknown is how cellular states of the ovarian reserve are established and maintained for decades. Our recent study revealed that a distinct chromatin state is established during ovarian reserve formation in mice, uncovering a novel window of epigenetic (...) programming in female germline development. We showed that an epigenetic regulator, Polycomb Repressive Complex 1 (PRC1), establishes a repressive chromatin state in perinatal mouse oocytes that is essential for prophase I‐arrested oocytes to form the ovarian reserve. Here we discuss the biological roles and mechanisms underlying epigenetic programming in ovarian reserve formation, highlighting current knowledge gaps and emerging research areas in female reproductive biology. (shrink)

Criticism and interpretation of Zawāhir al-ḥikam by Ḥasan ibn ʻAbd al-Razzāq Lāhījī, 1635 or 1636-1709 or 1710; Islamic philosophy - Early works to 1800; Shīʻah - Doctrines - Early works to 1800.

In this philosophically sophisticated and historically significant work, John H. Zammito reconstructs Kant's composition of The Critique of Judgment and reveals that it underwent three major transformations before publication. He shows that Kant not only made his "cognitive" turn, expanding the project from a "Critique of Taste" to a Critique of Judgment but he also made an "ethical" turn. This "ethical" turn was provoked by controversies in German philosophical and religious culture, in particular the writings of Johann Herder and the (...) Sturm und Drang movement in art and science, as well as the related pantheism controversy. Such topicality made the Third Critique pivotal in creating a "Kantian" movement in the 1790s, leading directly to German Idealism and Romanticism. The austerity and grandeur of Kant's philosophical writings sometimes make it hard to recognize them as the products of a historical individual situated in the particular constellation of his time and society. Here Kant emerges as a concrete historical figure struggling to preserve the achievements of cosmopolitan Aufkl-rung against challenges in natural science, religion, and politics in the late 1780s. More specifically Zammito suggests that Kant's Third Critique was animated throughout by a fierce personal rivalry with Herder and by a strong commitment to traditional Christian ideas of God and human moral freedom. "A work of extraordinary erudition. Zammito's study is both comprehensive and novel, connecting Kant's work with the aesthetic and religious controversies of the late eighteenth century. He seems to have read everything. I know of no comparable historical study of Kant's Third Critique."-Arnulf Zweig, translator and editor of Kant's ;IPhilosophical Correspondence, 1759-1799;X "An intricate, subtle, and exciting explanation of how Kant's thinking developed and adjusted to new challenges over the decade from the first edition of the Critique of Pure Reason to the appearance of the Critique of Judgment. "--John W. Burbidge, Review of Metaphysics "There has been for a long time a serious gap in English commentary on Kant's Critique of Judgment Zammito's book finally fills it. All students and scholars of Kant will want to consult it."--Frederick Beiser, Times Literary Supplement. (shrink)

Refusal of organ donation is common, and becoming more frequent. In Australia refusal by families occurred in 56% of cases in 1995 in New South Wales, and had risen to 82% in 1999, becoming the most important determinant of the country's very low organ donation rate .Leading causes of refusal, identified in many studies, include the lack of understanding by families of brain death and its implications, and subsequent reluctance to relegate the body to purely instrumental status. It is an (...) interesting paradox that surveys of the public continue to show considerable support for organ donation programmes—in theory we will, in practice we won't .In this paper we propose that the Australian community may, for good reason, distrust the concept of and criteria for “whole brain death”, and the equation of this new concept with death of the human being. We suggest that irreversible loss of circulation should be reinstated as the major defining characteristic of death, but that brain-dead, heart-beating entities remain suitable organ donors despite being alive by this criterion. This presents a major challenge to the “dead donor rule”, and would require review of current transplantation legislation. Brain dead entities are suitable donors because of irreversible loss of personhood, accurately and robustly defined by the current brain stem criteria."Even the dead are not terminally ill any more.". (shrink)

At 2.00 am on the morning of May 24, 1995 the Northern Territory Legislative Assembly Australia passed the Rights of the Terminally Ill Act by the narrow margin of 15 votes to 10. The act permits a terminally ill patient of sound mind and over the age of 18 years, and who is either in pain or suffering, or distress, to request a medical practitioner to assist the patient to terminate his or her life. Thus, Australia can lay claim to (...) being the first country in the world to legalise voluntary active euthanasia. The Northern Territory's act has prompted Australia-wide community reaction, particularly in South Australia, Tasmania and the Australian Capital Territory where proposals to legalise euthanasia have already been defeated on the floor of parliament. In New South Wales (NSW) the AIDS Council of NSW has prepared draft euthanasia legislation to be introduced into the Upper House as a Private Member's Bill some time in 1996. In this paper, we focus on a brief description of events as they occurred and on the arguments for and against the legalisation of euthanasia which have appeared in the media. (shrink)

Ghazzālī, 1058-1111; Kīmiyā-yi saʻādat -Criticism and interpretation ; Ghazzālī, Aḥmad ibn Muḥammad, -1126; Savāniḥ -Criticism and interpretation ; Ghazzālī, Aḥmad ibn Muḥammad, -1126; Baḥr al-muḥabbat fī asrār al-muvaddat fītafsīr Sūrah-i Yūsuf -Criticism.

The vacuum structure for the massive charged scalar field in the region of two parallel, infinitely long and thin solenoids confining the fluxesn 1 andn 2 is studied. By using the Green function method, it is found that the vacuum expectation value of the system's energy has a finite mutual interaction term depending on the distance a between the solenoids, which implies an attractive force per unit length given by F n1n2 =−(ℏc/π2)(n 1 n 2)2/a 3.

الفكر، والتَّفكير، والتَّفكُّر، والتَّدبُّر، والتَّذكُّر،... مفاهيمُ أساسية رافقت الوجود الإنساني، منذ بدء الخليقة، وسوف تبقى معه إلى نهايتها، دون أن تثبت مادتها وموضوعاتها ومستوياتها عند حد معين، في حياة الفرد البشري أو الجيل البشري. فكيف يمكن لكتاب أن يستقصي ذلك؟! هذا الكتاب إذاً، مدخل إلى الفكر وحسب؛ مدخل في مفاهيمه ومستوياته وخرائطه... تضمن تجوالاً فكرياً: في موضوع الفكر؛ وفي مصادره في الأصول والتراث والخبرة المعاصرة، وموضوعاته، وأدواته، ونصيب أصناف أهله منه، والمؤسسات المتخصصة فيه، وعلاقته بالعلم جملة، وبالعلوم النفسية والتربوية والاجتماعية (...) واللغوية والسياسية... وهو كذلك مدخل إلى عملية البناء الفكري؛ كيف تبدأ، ثم تتواصل مرحلة بعد أخرى؟ وكيف تترقى من مستوى إلى آخر؟ وكيف تتنوع في المحتوى الذي تبنيه؟ وهو قبل ذلك وبعده، أسئلة كثيرة، وإجابات قليلة؛ فقيمةُ التَّفكُّر في إثارة الأسئلة لا تقلُّ عن التفكر في البحث عن إجاباتها، وبعض الإجابات عارضة مؤقتة، تتغير وتتعمق مع مزيد من الفكْر والذِّكْر، والتَّفكُّر والتَّذكُّر. قد يجد القارئ في الكتاب بعض مواطن المتعة والطرافة، لكنه سوف يجد كذلك مواطن كثيرة تضطره إلى التَّفكُّر والتَّدبُّر، فإذا نجح الكتاب في الأمرين، فذلك ما كان يهدف إليه!. (shrink)

الفكر، والتَّفكير، والتَّفكُّر، والتَّدبُّر، والتَّذكُّر،... مفاهيمُ أساسية رافقت الوجود الإنساني، منذ بدء الخليقة، وسوف تبقى معه إلى نهايتها، دون أن تثبت مادتها وموضوعاتها ومستوياتها عند حد معين، في حياة الفرد البشري أو الجيل البشري. فكيف يمكن لكتاب أن يستقصي ذلك؟! هذا الكتاب إذاً، مدخل إلى الفكر وحسب؛ مدخل في مفاهيمه ومستوياته وخرائطه... تضمن تجوالاً فكرياً: في موضوع الفكر؛ وفي مصادره في الأصول والتراث والخبرة المعاصرة، وموضوعاته، وأدواته، ونصيب أصناف أهله منه، والمؤسسات المتخصصة فيه، وعلاقته بالعلم جملة، وبالعلوم النفسية والتربوية والاجتماعية (...) واللغوية والسياسية... وهو كذلك مدخل إلى عملية البناء الفكري؛ كيف تبدأ، ثم تتواصل مرحلة بعد أخرى؟ وكيف تترقى من مستوى إلى آخر؟ وكيف تتنوع في المحتوى الذي تبنيه؟ وهو قبل ذلك وبعده، أسئلة كثيرة، وإجابات قليلة؛ فقيمةُ التَّفكُّر في إثارة الأسئلة لا تقلُّ عن التفكر في البحث عن إجاباتها، وبعض الإجابات عارضة مؤقتة، تتغير وتتعمق مع مزيد من الفكْر والذِّكْر، والتَّفكُّر والتَّذكُّر. قد يجد القارئ في الكتاب بعض مواطن المتعة والطرافة، لكنه سوف يجد كذلك مواطن كثيرة تضطره إلى التَّفكُّر والتَّدبُّر، فإذا نجح الكتاب في الأمرين، فذلك ما كان يهدف إليه! (shrink)